Aviva Systems Biology will be closed in observance of Good Friday 3/29/2024. If you are in need of any assistance please email info@avivasysbio.com

Catalog No: OACD07546
Price: $0.00
SKU
OACD07546
Availability: Domestic: within 1-2 weeks delivery | International: within 1-2 weeks delivery
Bulk
Order
Aviva's
Satisfaction
Guarantee
Contact Us:
Shipping Info:
  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.
Datasheets/ManualsPrintable datasheet for STK3 Antibody (OACD07546)
Product Info
Predicted Species ReactivityHuman|Mouse
Product FormatLiquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ApplicationImmunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Reconstitution and Storage2°C to 8°C|-20°C
ImmunogenRange: Thr235 - Ala460
PurificationAffinity Purified; Protein A Purified
Concentration0.5 mg/ml
Preservative0.02% NaN3
SpecificityThe antibody is a rabbit polyclonal antibody raised against STK3. It has been selected for its ability to recognize STK3 in immunohistochemical staining and western blotting.
FormulationPBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Application DataWestern blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-1:5,000
Optimal working dilutions must be determined by end user.
Gene SymbolStk3
Gene Full Nameserine/threonine kinase 3
Alias Symbols0610042I06Rik;mammalian STE20-like protein kinase 2;mes;mess1;MS;MST;Mst2;MST-2;Mst3;protein kinase homolog;serine/threonine-protein kinase 3;Ste2;Ste20;STE20-like kinase MST2.
NCBI Gene Id56274
Protein NameSerine/threonine-protein kinase 3
Description of TargetStress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1. Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (By similarity).
Uniprot IDQ9JI10
Protein Accession #NP_062609.2
Nucleotide Accession #NM_019635
Molecular Weight49 kDa
  1. What is the species homology for "STK3 Antibody (OACD07546)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse".

  2. How long will it take to receive "STK3 Antibody (OACD07546)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: within 1-2 weeks delivery".

  3. What buffer format is "STK3 Antibody (OACD07546)" provided in?

    This item is provided in "Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "STK3 Antibody (OACD07546)"?

    This target may also be called "0610042I06Rik;mammalian STE20-like protein kinase 2;mes;mess1;MS;MST;Mst2;MST-2;Mst3;protein kinase homolog;serine/threonine-protein kinase 3;Ste2;Ste20;STE20-like kinase MST2." in publications.

  5. What is the shipping cost for "STK3 Antibody (OACD07546)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "STK3 Antibody (OACD07546)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "STK3 Antibody (OACD07546)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "49 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "STK3 Antibody (OACD07546)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "Stk3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "Stk3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "Stk3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "Stk3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "Stk3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "Stk3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

Write Your Own Review
You're reviewing:STK3 Antibody (OACD07546)
Your Rating
We found other products you might like!