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Sti1p (HOP) Antibody (OASE00431)

  • Catalog#: OASE00431
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100ul
$325.00
Discontinued
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Conjugation Options

OASE00431-FITC Conjugated

OASE00431-HRP Conjugated

OASE00431-Biotin Conjugated

Gene Symbol:
STI1
NCBI Gene Id:
854192
Swissprot Id:
P15705
Protein Accession #:
NP_014670.1
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Rabbit antiserum
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express STI1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express STI1.
Immunogen:
Yeast Sti1p raised against peptide(CDINQSNSMPKEPET)-KLH fusion
Predicted Species Reactivity:
Yeast
Reconstitution and Storage:
Store at -20C. Shipping in Blue Ice or 4C.
Datasheets/Manuals:
Printable datasheet for OASE00431
Dilution:
1:2500 (WB)
Additional Information:
Background Info: Detects ~ 66kDa band
:::
Scientific Background: The stress inducible protein Sti1p is also commonly known as Hsp70-Hsp90 organization protein (HOP). It is located in diverse cellular regions and can move between the cytoplasm and the nucleus. It functions to reversibly link together the protein chaperones Hsp70 and Hsp90. HOP contains three tetratricopeptide repeat (TPR) domains, TPR1, TPR2a and TPR2b. Hsp70 binding has been localized to TRP1 and sp90 binding have been localized to TPR2a (1). It has also been found to modulate the chaperone activities of the linked proteins and possible interacts with other chaperones and proteins. It has also been found to participate in other complexes besides the Hsp70/Hsp90 one (2). HOP is closely related to human 63kDa protein that is sensitive to simian virus SV40 transformation, and is related to the yeast heat-shock- responsive STI1 gene product (3, 4).
:::
Certificate of Analysis: 0.5 ug/mL was sufficient for detection of Sti1p (HOP) in 20 ug of W303 yeast lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Target Reference:
1. Flom G., Behal R.H., Rosen L., Cole D.G., Johnson J.L. (2007) Biochem J. 404(1): 159-167.
2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt3): 789-796.
3. Honore B.H., et al. (1992) J Biol Chem. 267: 8485- 8491.
4. Nicolet C.M., et al. (1989) Mol Cell Bio. 9: 3638-3646.
Storage Buffer:
Rabbit antiserum in PBS and 50% glycerol

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