Size:100 ul
$315.00
In Stock
SKU
OACA02429
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More Information
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ApplicationWB, IHC, CHIP
Reconstitution and StorageStore at 4C for up to one month. For long term storage, aliquot and store at -20C or -80C. Avoid freeze thaw cycles.
Replacement ItemThis antibody may replace item sc-116946 from Santa Cruz Biotechnology.
ImmunogenRecombinant human Signal transducer and activator of transcription 5B protein (40-280aa)
PurificationAntigen Affinity Purified
Predicted Homology Based on Immunogen SequenceHuman
Datasheets/ManualsPrintable datasheet for anti-STAT5B (OACA02429) antibody
SpecificityHuman
FormulationProvided in PBS, pH 7.3, 50% Glycerol, 0.02% Sodium Azide
Application DataWB:1:500-2000, IHC:1:20-1:200
Target Reference[1] A Novel Missense Mutation in the SH2 Domain of the STAT5B Gene Results in a transcriptionally inactive STAT5b associated with severe IGF-I deficiency, immune dysfunction, and lack of pulmonary disease. Scaglia P.A., Martinez A.S., Feigerlova E., Bezrodnik L., Gaillard M.I., Di Giovanni D., Ballerini M.G., Jasper H.G., Heinrich J.J., Fang P., Domene H.M., Rosenfeld R.G., Hwa V. J. Clin. Endocrinol. Metab. 97:E830-839 (2012).
[2] Growth hormone insensitivity associated with a STAT5b mutation. Kofoed E.M., Hwa V., Little B., Woods K.A., Buckway C.K., Tsubaki J., Pratt K.L., Bezrodnik L., Jasper H., Tepper A., Heinrich J.J., Rosenfeld R.G.N. Engl. J. Med. 349:1139-1147 (2003).
[3] Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. Chaix A., Lopez S., Voisset E., Gros L., Dubreuil P., De Sepulveda P.J. Biol. Chem. 286:5956-5966 (2011).
Gene SymbolSTAT5B
Official Gene Full Namesignal transducer and activator of transcription 5B
Alias SymbolsSTAT5
NCBI Gene Id6777
Protein Namesignal transducer and activator of transcription 5B
Description of TargetThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Swissprot IdP51692
Protein Accession #NP_036580.2
Nucleotide Accession #NM_012448.3
Protein Size (# AA)787
Molecular Weight90 kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express STAT5B.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express STAT5B.
  1. What is the species homology for "STAT5B Antibody (OACA02429)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "STAT5B Antibody (OACA02429)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "STAT5B Antibody (OACA02429)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "STAT5B Antibody (OACA02429)"?

    This target may also be called "STAT5" in publications.

  5. What is the shipping cost for "STAT5B Antibody (OACA02429)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "STAT5B Antibody (OACA02429)"?

    All Aviva products have been through vigorous validations and carry 100% satisfaction warranty.

  7. Can I get bulk pricing for "STAT5B Antibody (OACA02429)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "90 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "STAT5B Antibody (OACA02429)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "STAT5B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "STAT5B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "STAT5B"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "STAT5B"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "STAT5B"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "STAT5B"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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