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STAT5B Antibody (OACA02429)

100 ul
$315.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB, IHC, CHIP
Reconstitution and Storage:
Store at 4C for up to one month. For long term storage, aliquot and store at -20C or -80C. Avoid freeze thaw cycles.
Replacement Item:
This antibody may replace item sc-116946 from Santa Cruz Biotechnology.
Immunogen:
Recombinant human Signal transducer and activator of transcription 5B protein (40-280aa)
Purification:
Antigen Affinity Purified
Predicted Homology Based on Immunogen Sequence:
Human
Datasheets/Manuals:
Printable datasheet for anti-STAT5B (OACA02429) antibody
Specificity:
Human
Formulation:
Provided in PBS, pH 7.3, 50% Glycerol, 0.02% Sodium Azide
Application Data:
WB:1:500-2000, IHC:1:20-1:200
Target Reference:
[1] A Novel Missense Mutation in the SH2 Domain of the STAT5B Gene Results in a transcriptionally inactive STAT5b associated with severe IGF-I deficiency, immune dysfunction, and lack of pulmonary disease. Scaglia P.A., Martinez A.S., Feigerlova E., Bezrodnik L., Gaillard M.I., Di Giovanni D., Ballerini M.G., Jasper H.G., Heinrich J.J., Fang P., Domene H.M., Rosenfeld R.G., Hwa V. J. Clin. Endocrinol. Metab. 97:E830-839 (2012).
[2] Growth hormone insensitivity associated with a STAT5b mutation. Kofoed E.M., Hwa V., Little B., Woods K.A., Buckway C.K., Tsubaki J., Pratt K.L., Bezrodnik L., Jasper H., Tepper A., Heinrich J.J., Rosenfeld R.G.N. Engl. J. Med. 349:1139-1147 (2003).
[3] Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. Chaix A., Lopez S., Voisset E., Gros L., Dubreuil P., De Sepulveda P.J. Biol. Chem. 286:5956-5966 (2011).
Gene Symbol:
STAT5B
Official Gene Full Name:
signal transducer and activator of transcription 5B
Alias Symbols:
STAT5
NCBI Gene Id:
6777
Protein Name:
signal transducer and activator of transcription 5B
Description of Target:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Swissprot Id:
P51692
Protein Accession #:
NP_036580.2
Nucleotide Accession #:
NM_012448.3
Protein Size (# AA):
787
Molecular Weight:
90 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express STAT5B.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express STAT5B.

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