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Catalog No: OAAB17114
Size:400ul
Price: $438.00
SKU
OAAB17114
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAB17114
Product Info
Predicted Species ReactivityHuman, Mouse
Product FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationWB, IHC
Additional InformationPrecautions: SRPK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
::Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles
::Cellular Location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation
Tissue Location: Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis SRPK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-495 amino acids from the C-terminal region of human SRPK2.
Predicted Homology Based on Immunogen SequenceHuman; Mouse
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Application InfoWB: 1:1000
IHC-P: 1:50~100
Gene SymbolSRPK2
Alias SymbolsSFRSK2
NCBI Gene Id6733
Protein NameSRSF protein kinase 2
Description of TargetPurified Rabbit Polyclonal Antibody (Pab)
Uniprot IDP78362
Protein Accession #NP_872633.1
Molecular Weight77527 Da
  1. What is the species homology for "SRPK2 Antibody - C-terminal region (OAAB17114)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".

  2. How long will it take to receive "SRPK2 Antibody - C-terminal region (OAAB17114)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "SRPK2 Antibody - C-terminal region (OAAB17114)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SRPK2 Antibody - C-terminal region (OAAB17114)"?

    This target may also be called "SFRSK2" in publications.

  5. What is the shipping cost for "SRPK2 Antibody - C-terminal region (OAAB17114)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SRPK2 Antibody - C-terminal region (OAAB17114)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SRPK2 Antibody - C-terminal region (OAAB17114)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "77527 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SRPK2 Antibody - C-terminal region (OAAB17114)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SRPK2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SRPK2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SRPK2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SRPK2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SRPK2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SRPK2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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