SREBF1 Recombinant Protein (OPCD00737)

Catalog No: OPCD00737

SREBF1 Recombinant Protein (OPCD00737) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Ctrl (+), SDS-PAGE, WB
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Pro158-Leu390
  Subcellular Location: Membrane, Golgi apparatus, Endoplasmic reticulum lumen
  Isoelectric Point: 10.2
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Srebf1
• Gene Full Name: sterol regulatory element binding transcription factor 1
• Alias Symbols: ADD-;ADD1;adipocyte determination- and differentiation-dependent factor 1;bHLHd;bHLHd1;SRE;SREB;SREBP;SREBP1;sterol regulatory element-binding protein 1;Sterol regulatory element-binding transcription factor 1.
• NCBI Gene Id: 20787
• Protein Name: Sterol regulatory element-binding protein 1
• Description of Target: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters.
• Uniprot ID: Q9WTN3
• Protein Accession #: NP_001300908.1
• Nucleotide Accession #: NM_001313979.1
• Protein Size (# AA): Pro158~Leu390
• Molecular Weight: 27kDa