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SREBF1 Protein Lysate (APL10610)

200ug
$219.00
In Stock
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Gene Symbol:
SREBF1
Alias Symbols:
SREBP1, bHLHd1, SREBP-1c
NCBI Gene Id:
6720
Protein Name:
Sterol regulatory element-binding protein 1
Swissprot Id:
P36956
Protein Accession #:
NP_004167.3
Nucleotide Accession #:
NM_004176.3
Description of Target:
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
Molecular Weight:
60
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SREBF1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SREBF1.
Protein Interactions:
UBC; ERLIN2; FBXW7; SMARCD3; HSP90AA1; SUMO1; ATXN1L; INSIG2; SCAP; ATXN1; LMNA; INSIG1; EGF; SREBF2; SREBF1; ZBTB7A; ZBTB7C; SUMO2; MED6; MED13; MED12; MED24; MED26; MED17; MED23; MED14; USF1; MED1; GSK3B; CREBBP; CDK8; MED25; MED15; MED7; MED21; SIRT1;
Quality Control:
This product was tested on western blot.
Application : Western blot standard.
Observed Molecular Weight: 59
Expression system : Bacteria
Tag:
GST in N-terminal
Reconstitution and Storage:
Add 200ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Datasheets/Manuals:
Printable datasheet for anti-SREBF1 (APL10610) antibody

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