sRAGE Protein (OPPA01767)

Catalog No: OPPA01767 (Formerly GWB-EFC096)

Size:2UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: The filtered (0.4 um) concentrated (0.5mg/ml) protein solution was lyophilized with 50mM Tris-HCl pH-7.5 & 50mM NaCl. Physical appearance: Filtered White lyophilized (freeze-dried) powder.
• Host: HEK293 (Human Embryonic Kidney Cell Line)
• Additional Information: Solubility: Add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
  Product Introduction: sRAGE is a member of the immunoglobulin superfamily of cell surface molecules. sRAGE is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. sRAGE lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms. sRAGE mediates interactions of nonenzymatic glycosylated proteins which accumulate in vascular tissue during aging & at an increasing rate in diabetes. sRAGE is a receptor for amyloid beta peptide.
  Product Description: sRAGE Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing 331 amino acids and having a molecular mass of 35.2 kDa. sRAGE Human is fused to Flag tag at C-Terminus.sRAGE Human is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: Store lyophilized protein at -20C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4C for a limited period of time.
• Purity: Greater than 95% as determined by SDS-PAGE.
• Peptide Sequence: AQNITARIGEPLVLKCKGAPKKPPQRLEWK LNTGRTEAWK VLSPQGGGPW DSVARVLPNG SLFLPAVGIQ DEGIFRCQAM NRNGKETKSN YRVRVYQIPG KPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGK PLVPNEKGVS VKEQTRRHPE TGLFTLQSEL MVTPARGGDP RPTFSCSFSP GLPRHRALRT APIQPRVWEP VPLEEVQLVV EPEGGAVAPG GTVTLTCEVP AQPSPQIHWM KDGVPLPLPP SPVLILPEIG PQDQGTYSCV ATHSSHGPQE SRAVSISIIE PGEEGPTAGS VGGSGLGTLA AAADYKDDDDK.
• Source: HEK293 Cells

Target Info

• Gene Symbol: sRAGE HEK
• Alias Symbols: RAGE, sRAGE, SCARJ1
• NCBI Gene Id: 177
• Protein Name: Advanced glycosylation end product-specific receptor
• Description of Target: Recombinant Human Advanced Glycosylation End Product-Specific Receptor, HEK
• Uniprot ID: Q15109
• Protein Accession #: NP_001127.1
• Protein Size (# AA): Recombinant