sRAGE Protein (OPPA01766)

Catalog No: OPPA01766 (Formerly GWB-1D1558)

Size:2UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized 30mM acetate buffer (pH 4)
• Host: E. Coli
• Reconstitution and Storage: Store lyophilized protein at -20°C. Add 0.1M Acetate buffer (pH 4) to a working concentration of 0.5 mg/ml and let the lyophilized pellet dissolve completely. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time.
• Purification: Proprietary chromatographic techniques.
• Concentration: 0.5 mg/ml (prior to lyophilization)
• Purity: Greater than 95% as determined by SDS-PAGE.
• Protein Sequence: MRGSHHHHHH GMASAQNITA RIGEPLVLKC KGAPKKPPQR LEWKLNTGRT EAWKVLSPQG GGPWDSVARV LPNGSLFLPAV GIQDEGIFRCQ AMNRNGKETKS NYRVRVYQIP GKPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGKPL VPNEKGVSVK EQTRRHPETG LFTLQSELMV TPARGGDPRP TFSCSFSPGL PRHRALRTAP IQPRVWEPVPL EEVQLVVEPE GGAVAPGGTV TLTCEVPAQP SPQIHWMKDGVP LPLPPSPVLI LPEIGPQDQG TYSCVATHSS HGPQESRAVS ISIIEPGEEG PTAGEGFDKV REAEDSPQHM
• Tag: N-terminal His-tag

Target Info

• Gene Symbol: sRAGE
• Alias Symbols: RAGE, sRAGE, SCARJ1
• NCBI Gene Id: 177
• Protein Name: Advanced glycosylation end product-specific receptor
• Description of Target: sRAGE is a member of the immunoglobulin superfamily of cell surface molecules. sRAGE is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. sRAGE lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms. sRAGE mediates interactions of nonenzymatic glycosylated proteins which accumulate in vascular tissue during aging & at an increasing rate in diabetes. sRAGE is a receptor for amyloid beta peptide. sRAGE Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 134 amino acids.
• Uniprot ID: Q15109
• Protein Accession #: NP_001127.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 36.5 kDa