SQSTM1 Antibody (Phospho-Ser207) (OAAB16350)

Catalog No: OAAB16350

Size:400ul

Dot blot analysis of SQSTM1 Antibody (Phospho S207) Phospho-specific Pab (Cat. # OAAB16350) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Product Info

• Predicted Species Reactivity: Human
• Product Format: LiquidPBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: DB, ELISA
• Additional Information: Cellular Location: Cytoplasm. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Cytoplasm, P-body. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary
  Tissue Location: Ubiquitously expressed.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This SQSTM1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S207 of human SQSTM1.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: 0.5 mg/ml
• Application Info: DB: 1:500

Target Info

• Gene Symbol: SQSTM1
• Alias Symbols: p60, p62, A170, DMRV, OSIL, PDB3, ZIP3, p62B, NADGP, FTDALS3
• NCBI Gene Id: 8878
• Protein Name: Sequestosome-1
• Description of Target: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
• Uniprot ID: Q13501
• Protein Accession #: NP_001135770.1
• Molecular Weight: 48 kDa