SPTB Antibody (OAAD00200)

Catalog No: OAAD00200

Size:100 ug

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: Spe 1/2
• Isotype: IgG1
• Host: Mouse
• Application: WB
• Reconstitution and Storage: At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for longer time.
• Immunogen: Human erythrocyte spectrin.
• Purification: Purified by the goat anti-mouse IgG Affinity chromatography.
• Specificity: Human.
  No cross reactivity with other proteins.
• Formulation: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mg NaN3 as preservative.
• Application Info: Western blot At 2-4ug/ml with the appropriate system to detect spectrin in cells and tissues.
  Other applications have not been tested.
  Optimal dilutions should be determined by end user.
• Storage Buffer: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
• Reference: 1. Watkins, P. C.; Eddy, R.; Forget, B. G.; Chang, J. G.; Rochelle, R.; Shows, T. B. : Assignment of a non-erythroid spectrin gene to human chromosome 2. (Abstract) Am. J. Hum. Genet. 43: A161, 1988.
  2. Ikeda, Y.; Dick, K. A.; Weatherspoon, M. R.; Gincel, D.; Armbrust, K. R.; Dalton, J. C.; Stevanin, G.; Durr, A.; Zuhlke, C.; Burk, K.; Clark, H. B.; Brice, A.; Rothstein, J. D.; Schut, L. J.; Day, J. W.; Ranum, L. P. W. : Spectrin mutations cause spinocerebellar ataxia type 5. Nature Genet. 38: 184-190, 2006.

Target Info

• Gene Symbol: SPTB
• Gene Full Name: Spectrin beta chain, erythrocytic
• Alias Symbols: EL3, HS2, SPH2, HSPTB1
• NCBI Gene Id: 6710
• Protein Name: Spectrin beta chain, erythrocytic
• Description of Target: Spectrin, the predominant component of the membrane skeleton of the red cell, is essential in determining the properties of the membrane including its shape and deformability. It consists of 2 nonidentical subunits, alpha and beta. Spectrin is present in the red cell membrane in a tetrameric or possibly higher polymeric form through head-to-head self-association of heterodimers that are linked by actin polymers and protein 4.1 to form a 2-dimensional network. Non-erythroid spectrin gene is mapped to human chromosome 2.Spectrin mutations cause spinocerebellar ataxia type 5.
• Uniprot ID: P11277
• Protein Accession #: NP_000338.3; NP_001020029.1; XP_005268080.1
• Nucleotide Accession #: NM_000347.5; NM_001024858.2; XM_005268023.3