SPPL2a Antibody - N-terminal region (OAAB16632)

Catalog No: OAAB16632 (Formerly GWB-U5VM95)

Size:400ul

The anti-SPPL2a Pab (Cat. # OAAB16632) is used in Western blot to detect SPPL2a in Jurkat cell lysate.

Formalin-fixed and paraffin-embedded placenta tissue reacted with SPPL2a Antibody (N-term) (Cat.# OAAB16632), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC
• Additional Information: Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity
  Cellular Location: Late endosome membrane; Multi-pass membrane protein (By similarity). Lysosome membrane; Multi-pass membrane protein (By similarity). Cell membrane. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane
  Tissue Location: Ubiquitous.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This SPPL2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-138 amino acids from the N-terminal region of human SPPL2a.
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Intended Use: SPPL2a Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1000
  IHC-P: 1:10~50

Target Info

• Gene Symbol: SPPL2A
• Alias Symbols: IMP3, PSL2
• NCBI Gene Id: 84888
• Protein Name: Signal peptide peptidase-like 2A
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q8TCT8
• Protein Accession #: NP_116191.2
• Molecular Weight: 58143 Da