- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for SPN Antibody (OAAF08262) |
---|
Tested Species Reactivity | Human |
---|---|
Predicted Species Reactivity | Human |
Product Format | PBS, pH7.2, 0.03% Proclin 300, 50% glycerol |
Clonality | Monoclonal |
Clone | ABT-CD43 |
Isotype | IgG |
Host | Mouse |
Application | Immunohistochemistry |
Additional Information | Retrieval buffer: Citrate buffer of pH6.0 |
:: | Description: Mouse monoclonal to CD43 |
Reconstitution and Storage | -20°C |
Immunogen | Synthetic peptide. |
Purification | Immunogen affinity purified |
Specificity | Anti-CD43 [ABT-CD43] detects endogenous levels of total CD43 protein. |
Application Info | IHC 1:200 - 1:400 |
Gene Symbol | SPN |
---|---|
Gene Full Name | sialophorin |
Alias Symbols | CD43;galactoglycoprotein;GALGP;GPL115;leukocyte sialoglycoprotein;leukosialin;LSN;Sialophorin;sialophorin (gpL115, leukosialin, CD43). |
NCBI Gene Id | 6693 |
Protein Name | Leukosialin |
Description of Target | Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). |
Uniprot ID | P16150 |
Protein Accession # | NP_001025459.1 |
Nucleotide Accession # | NM_003123.4 |
Molecular Weight | 40 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
-
What is the species homology for "SPN Antibody (OAAF08262)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".
-
How long will it take to receive "SPN Antibody (OAAF08262)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
-
What buffer format is "SPN Antibody (OAAF08262)" provided in?
This item is provided in "PBS, pH7.2, 0.03% Proclin 300, 50% glycerol".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "SPN Antibody (OAAF08262)"?
This target may also be called "CD43;galactoglycoprotein;GALGP;GPL115;leukocyte sialoglycoprotein;leukosialin;LSN;Sialophorin;sialophorin (gpL115, leukosialin, CD43)." in publications.
-
What is the shipping cost for "SPN Antibody (OAAF08262)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
-
What is the guarantee for "SPN Antibody (OAAF08262)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "SPN Antibody (OAAF08262)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "40 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "SPN Antibody (OAAF08262)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "SPN"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "SPN"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "SPN"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "SPN"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "SPN"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "SPN"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.