SPATA18 Antibody - middle region (ARP52838_P050)

Catalog No: ARP52838_P050

Host: Rabbit
Target Name: SPATA18
Sample Tissue: Human HT1080 Whole Cell lysates
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SPATA18
• Purification: Affinity purified
• Predicted Homology Based on Immunogen Sequence: Cow: 77%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: ELKSLQAQEDARHRNTDQRSSENRRSEPWSLEERKREQWNSLKQNADQQD
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-SPATA18 (ARP52838_P050) antibody is Catalog # AAP52838

Target Info

• Gene Symbol: SPATA18
• Gene Full Name: spermatogenesis associated 18
• Alias Symbols: Mieap, SPETEX1
• NCBI Gene Id: 132671
• Protein Name: Mitochondria-eating protein
• Description of Target: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
• Uniprot ID: Q8TC71-2
• Protein Accession #: NP_001284537
• Nucleotide Accession #: NM_001297608.1
• Protein Size (# AA): 506
• Molecular Weight: 55 kDa
• Protein Interactions: PAXIP1;