SP100 Recombinant Protein (OPCD07124)

Catalog No: OPCD07124

SP100 Recombinant Protein (OPCD07124) using SDS-PAGE

SP100 Recombinant Protein (OPCD07124) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gly610-Lys802
  Subcellular Location: Nucleus. Nucleus, PML body. Cytoplasm.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: SP100
• Gene Full Name: SP100 nuclear antigen
• Alias Symbols: lysp100b;nuclear autoantigen Sp-100;nuclear dot-associated Sp100 protein;SP100-HMG nuclear autoantigen;speckled 100 kDa.
• NCBI Gene Id: 6672
• Protein Name: Nuclear autoantigen Sp-100
• Description of Target: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.
• Uniprot ID: P23497
• Protein Accession #: NP_001073860.1
• Nucleotide Accession #: NM_001080391.1
• Protein Size (# AA): Gly610~Lys802
• Molecular Weight: 31kDa