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SP1 Antibody - C-terminal region (Phospho-P692) (OAAB07695)

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Gene Symbol:
NCBI Gene Id:
Protein Name:
Transcription factor Sp1
Swissprot Id:
Protein Accession #:
Alias Symbols:
SP1, TSFP1, Transcription factor Sp1
Replacement Item:
This antibody may replace item sc-14027 from Santa Cruz Biotechnology.
Description of Target:
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
80693 Da
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SP1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SP1.
This SP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 677-707 amino acids from the C-terminal region of human SP1.
Predicted Species Reactivity:
Human, Mouse, Rat
Predicted Homology Based on Immunogen Sequence:
Human; Mouse; Rat
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Printable datasheet for OAAB07695
Application Info:
WB: 1:500
WB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50
IF: 1:10~50
Additional Information:
Precautions: SP1 Antibody (C-term P692) is for research use only and not for use in diagnostic or therapeutic procedures.
Function: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression
Cellular Location: Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location
Tissue Location: Up-regulated in adenocarcinomas of the stomach (at protein level)

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