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SP1 Antibody - C-terminal region (Phospho-P692) (OAAB07695)

400ul
$390.00
In Stock
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Gene Symbol:
SP1
NCBI Gene Id:
6667
Protein Name:
Transcription factor Sp1
Swissprot Id:
P08047
Protein Accession #:
NP_001238754.1
Alias Symbols:
SP1, TSFP1, Transcription factor Sp1
Replacement Item:
This antibody may replace item sc-14027 from Santa Cruz Biotechnology.
Description of Target:
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
80693 Da
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB, IHC, FC, IF
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SP1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SP1.
Immunogen:
This SP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 677-707 amino acids from the C-terminal region of human SP1.
Predicted Species Reactivity:
Human, Mouse, Rat
Predicted Homology Based on Immunogen Sequence:
Human; Mouse; Rat
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB07695
Isotype:
Ig
Application Info:
WB: 1:500
WB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50
IF: 1:10~50
Additional Information:
Precautions: SP1 Antibody (C-term P692) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression
:::
Cellular Location: Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location
Tissue Location: Up-regulated in adenocarcinomas of the stomach (at protein level)

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