SORBS1 Antibody - middle region (OAAB00706)

Catalog No: OAAB00706

Size:400ul

SORBS1 Antibody (Center) (Cat. #OAAB00706) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SORBS1 antibody detected the SORBS1 protein (arrow).

SORBS1 Antibody (Center) (Cat. #OAAB00706) western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the SORBS1 antibody detected the SORBS1 protein (arrow).

Confocal immunofluorescent analysis of SORBS1 Antibody (Center) (Cat#OAAB00706) with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Product Info

• Predicted Species Reactivity: Human, Mouse, Hamster
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB, IF
  Function: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
  Cellular Location: Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion Nucleus. Nucleus matrix Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.
  Tissue Location Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.
  
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This SORBS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 866-892 amino acids from the Central region of human SORBS1.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Hamster
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Intended Use: SORBS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1000
  IF: 1:10~50

Target Info

• Gene Symbol: SORBS1
• Alias Symbols: CAP, FLAF2, R85FL, SH3D5, SORB1, SH3P12
• NCBI Gene Id: 10580
• Protein Name: Sorbin and SH3 domain-containing protein 1
• Description of Target: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
• Uniprot ID: Q9BX66
• Protein Accession #: NP_006425.2
• Molecular Weight: 142513 Da