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- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
| Datasheets/Manuals | Printable datasheet for SOCS1 Antibody (OACA03704) (OACA03704) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | Enzyme-linked immunosorbent assay|Immunohistochemistry |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Human Suppressor of cytokine signaling 1 protein (1-211AA) |
| Purification | Protein G Purified |
| Preservative | 0.03% Proclin 300 |
| Formulation | 50% Glycerol, 0.01M PBS, PH 7.4 |
| Reference | [1] "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3."Minamoto S., Ikegame K., Ueno K., Narazaki M., Naka T., Yamamoto H., Matsumoto T., Saito H., Hosoe S., Kishimoto T.Biochem. Bioph |
| Gene Symbol | SOCS1 |
|---|---|
| Gene Full Name | suppressor of cytokine signaling 1 |
| Alias Symbols | AISIMD;CIS1;CISH1;cytokine-inducible SH2 protein 1;JAB;JAK binding protein;JAK-binding protein;SOCS-1;SSI1;SSI-1;STAT induced SH3 protein 1;STAT-induced STAT inhibitor 1;suppressor of cytokine signaling 1;Tec-interacting protein 3;TIP3;TIP-3. |
| NCBI Gene Id | 8651 |
| Protein Name | Suppressor of cytokine signaling 1 |
| Description of Target | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. |
| Uniprot ID | O15524 |
| Protein Accession # | NP_003736 |
| Nucleotide Accession # | NM_003745 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "SOCS1 Antibody (OACA03704)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "SOCS1 Antibody (OACA03704)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "SOCS1 Antibody (OACA03704)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "SOCS1 Antibody (OACA03704)"?
This target may also be called "AISIMD;CIS1;CISH1;cytokine-inducible SH2 protein 1;JAB;JAK binding protein;JAK-binding protein;SOCS-1;SSI1;SSI-1;STAT induced SH3 protein 1;STAT-induced STAT inhibitor 1;suppressor of cytokine signaling 1;Tec-interacting protein 3;TIP3;TIP-3." in publications.
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What is the shipping cost for "SOCS1 Antibody (OACA03704)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "SOCS1 Antibody (OACA03704)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "SOCS1 Antibody (OACA03704)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "SOCS1 Antibody (OACA03704)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "SOCS1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "SOCS1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "SOCS1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "SOCS1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "SOCS1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "SOCS1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
