SNRP70 Antibody - C-terminal region : FITC (ARP40439_P050-FITC)

Catalog No: ARP40439_P050-FITC

Size:100ul

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Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: IHC, WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SNRP70
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: RERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDR
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-SNRNP70 (ARP40439_P050-FITC) antibody is Catalog # AAP40439 (Previous Catalog # AAPP22180)
• Sample Type Confirmation:

  SNRNP70 is supported by BioGPS gene expression data to be expressed in HepG2

• Reference: Brandenberger,R., (2004) Nat. Biotechnol. 22 (6), 707-716
• Publications:

  Franklin, S. et al. Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy. Mol. Cell. Proteomics 10, M110.000703 (2011). WB, IP, Human, Dog, Rabbit, Rat, Guinea pig, Bovine, Mouse 20807835

  Serini, S. et al. DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation. Carcinogenesis 33, 164-73 (2012). WB, IP, Human, Dog, Rabbit, Rat, Guinea pig, Bovine, Mouse 22045024

  Franklin, S. et al. Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. Mol. Cell. Proteomics 11, M111.014258 (2012). WB, IP, Human, Dog, Rabbit, Rat, Guinea pig, Bovine, Mouse 22270000

Target Info

• Gene Symbol: SNRNP70
• Gene Full Name: Small nuclear ribonucleoprotein 70kDa (U1)
• Alias Symbols: RPU1, Snp1, U1AP, U170K, U1RNP, RNPU1Z, SNRP70, U1-70K
• NCBI Gene Id: 6625
• Protein Name: U1 small nuclear ribonucleoprotein 70 kDa
• Description of Target: SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.
• Uniprot ID: P08621
• Protein Accession #: NP_003080
• Nucleotide Accession #: NM_003089
• Protein Size (# AA): 437
• Molecular Weight: 51kDa
• Protein Interactions: IL32; UBC; NEDD8; LIN28A; EZH2; SUZ12; EED; RNF2; rev; WBP4; SRPK2; SRPK1; MYC; SRPK3; HDAC2; PAN2; SMURF2; PRPF40A; CDKL3; RNF11; PRKD2; SKIL; RELA; RASGRF1; SMAD9; SMAD5; SMAD4; SMAD3; SMAD2; CHERP; PRMT5; UBL4A; VCAM1; SMAD1; ITGA4; IL7R; IFIT3; IFIT1;