SMN1 Recombinant Protein (OPCD07075)

Catalog No: OPCD07075

SMN1 more Recombinant Protein (OPCD07075) using SDS-PAGE

SMN1 more Recombinant Protein (OPCD07075) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Glu16-Pro251
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: SMN1|SMN2
• Gene Full Name: survival of motor neuron 1, telomeric|survival of motor neuron 2, centromeric
• Alias Symbols: BCD541;C-BCD541;component of gems 1;gemin-1;GEMIN1;SMA;SMA@;SMA1;SMA2;SMA3;SMA4;SMN;SMNC;SMNT;survival motor neuron 1 protein;survival motor neuron protein;T-BCD541;TDRD16A;TDRD16B;tudor domain containing 16A;tudor domain containing 16B.
• NCBI Gene Id: 6606|6607
• Protein Name: Survival motor neuron protein
• Description of Target: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
• Uniprot ID: Q16637
• Protein Accession #: NP_000335.1
• Nucleotide Accession #: NM_000344.3
• Protein Size (# AA): Glu16~Pro251
• Molecular Weight: 33kDa