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SMC3 Antibody (OACD07385)

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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB, ICC, IHC-P, IHC-F
Reconstitution and Storage:
Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles.
Official Gene Full Name:
Structural maintenance of chromosomes 3
NCBI Gene Id:
9126
Protein Name:
Structural maintenance of chromosomes protein 3
Swissprot Id:
Q9UQE7
Protein Accession #:
NP_005436.1
Nucleotide Accession #:
NM_005445
Alias Symbols:
BAM, bamacan, Bamacan, Basement membrane-associated chondroitin proteoglycan, BMH, CDLS3, Chondroitin sulfate proteoglycan 6, Chromosome-associated polypeptide, CSPG6, hCAP, HCAP, SMC-3, SMC3L1, SMC protein 3, Structural maintenance of chromosomes protein
Description of Target:
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.
Molecular Weight:
142 kDa
Purification:
Antigen-specific affinity chromatography
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SMC3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SMC3.
Immunogen:
Range: Ser994 - Glu1181
Concentration:
500ug/mL
Datasheets/Manuals:
Printable datasheet for anti-SMC3 (OACD07385) antibody
Preservative:
0.02% NaN3
Specificity:
The antibody is a rabbit polyclonal antibody raised against SMC3. It has been selected for its ability to recognize SMC3 in immunohistochemical staining and western blotting.
Formulation:
PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Application Data:
Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-1:5,000
Optimal working dilutions must be determined by end user.

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