SMARCB1 Antibody (OACA04796)

Catalog No: OACA04796

Immunohistochemistry of paraffin-embedded human kidney tissue at dilution 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue at dilution 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 protein (2-376AA)
• Purification: Protein G Purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, PH 7.4
• Reference: [1]"Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome." Tsurusaki Y., Okamoto N., Ohashi H., Kosho T., Imai Y., Hibi-Ko Y., Kaname T., Naritomi K., Kawame H., Wakui K., Fukushima Y., Homma T., Kato M., Hiraki Y., Yamagata T., Yano S., Mizuno S., Sakazume S. expand/collapse author list Matsumoto N. Nat. Genet. 44:376-378(2012). [2]"Evidence of a four-hit mechanism involving SMARCB1 and NF2 in schwannomatosis-associated schwannomas." Sestini R., Bacci C., Provenzano A., Genuardi M., Papi L. Hum. Mutat. 29:227-231(2008). [3]"Germline mutation of INI1/SMARCB1 in familial schwannomatosis." Hulsebos T.J.M., Plomp A.S., Wolterman R.A., Robanus-Maandag E.C., Baas F., Wesseling P. Am. J. Hum. Genet. 80:805-810(2007).

Target Info

• Gene Symbol: SMARCB1
• Gene Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
• Alias Symbols: BAF47;BRG1-associated factor 47;CSS3;hSNF5;hSNFS;INI1;integrase interactor 1 protein;malignant rhabdoid tumor suppressor;MRD15;PPP1R144;protein phosphatase 1, regulatory subunit 144;RDT;RTPS1;Sfh1p;SNF5;SNF5 homolog;SNF5L1;Snr1;sucrose nonfermenting, yeast, homolog-like 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF-related matrix-associated protein;SWNTS1.
• NCBI Gene Id: 6598
• Protein Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
• Description of Target: Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.
• Uniprot ID: Q12824
• Protein Accession #: NP_001007469
• Nucleotide Accession #: NM_001007468