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Datasheets/Manuals | Printable datasheet for SMARCA2 Antibody (OACA02435) (OACA02435) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Unconjugated |
Application | Chromatin immunoprecipitation|Enzyme-linked immunosorbent assay|Immunohistochemistry |
Reconstitution and Storage | -20°C or -80°C |
Immunogen | Recombinant Human Probable global transcription activator SNF2L2 protein (700-1216AA) |
Purification | Protein G Purified |
Predicted Homology Based on Immunogen Sequence | Human |
Specificity | Human |
Formulation | Provided in PBS, pH 7.4, 50% Glycerol, 0.03% Proclin 300 |
Reference | [1] A quantitative atlas of mitotic phosphorylation. Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767 (2008). [2] Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361 (2008). [3] Initial characterization of the human central proteome. Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17 (2011). |
Gene Symbol | SMARCA2 |
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Gene Full Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
Alias Symbols | ATP-dependent helicase SMARCA2;BAF190;BAF190B;BIS;brahma homolog;BRG1-associated factor 190B;BRM;global transcription activator homologous sequence;hBRM;hSNF2a;NCBRS;probable global transcription activator SNF2L2;protein brahma homolog;SNF2;SNF2/SWI2-like protein 2;SNF2-alpha;SNF2L2;SNF2LA;Sth1p;sucrose nonfermenting 2-like protein 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2;SWI2. |
NCBI Gene Id | 6595 |
Protein Name | Probable global transcription activator SNF2L2 |
Description of Target | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
Uniprot ID | P51531 |
Protein Accession # | NP_001276325.1 |
Nucleotide Accession # | NM_001289396.1 |
Protein Size (# AA) | 1590 |
Molecular Weight | 181 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "SMARCA2 Antibody (OACA02435)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "SMARCA2 Antibody (OACA02435)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "SMARCA2 Antibody (OACA02435)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "SMARCA2 Antibody (OACA02435)"?
This target may also be called "ATP-dependent helicase SMARCA2;BAF190;BAF190B;BIS;brahma homolog;BRG1-associated factor 190B;BRM;global transcription activator homologous sequence;hBRM;hSNF2a;NCBRS;probable global transcription activator SNF2L2;protein brahma homolog;SNF2;SNF2/SWI2-like protein 2;SNF2-alpha;SNF2L2;SNF2LA;Sth1p;sucrose nonfermenting 2-like protein 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2;SWI2." in publications.
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What is the shipping cost for "SMARCA2 Antibody (OACA02435)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "SMARCA2 Antibody (OACA02435)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "SMARCA2 Antibody (OACA02435)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "181 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "SMARCA2 Antibody (OACA02435)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "SMARCA2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "SMARCA2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "SMARCA2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "SMARCA2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "SMARCA2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "SMARCA2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.