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SMAD7 Antibody - N-terminal region (ARP32008_P050)

100 ul

Regular Price: $319.00

Special Price: $229.00

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Conjugation Options

ARP32008_P050-FITC Conjugated

ARP32008_P050-HRP Conjugated

ARP32008_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Cow, Dog, Human, Mouse, Pig, Rabbit, Rat
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
SMAD7
Official Gene Full Name:
SMAD family member 7
NCBI Gene Id:
4092
Protein Name:
Mothers against decapentaplegic homolog 7
Swissprot Id:
O15105
Protein Accession #:
NP_005895
Nucleotide Accession #:
NM_005904
Alias Symbols:
CRCS3, MADH7, MADH8
Replacement Item:
This antibody may replace item sc-101152 from Santa Cruz Biotechnology.
Description of Target:
Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition.
Protein Size (# AA):
426
Molecular Weight:
46kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SMAD7.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SMAD7.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD7
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Dog: 93%; Human: 100%; Mouse: 92%; Pig: 93%; Rabbit: 93%; Rat: 85%
Complete computational species homology data:
Anti-SMAD7 (ARP32008_P050)
Peptide Sequence:
Synthetic peptide located within the following region: EEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHH
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
HDAC3; HDAC2; USP11; SMURF2; SMURF1; SKP2; MYC; Melk; HCVgp1; RNF111; KDM2A; SOX13; PIAS1; SOX7; UBE2O; MKL2; ASH1L; PIAS4; CXXC5; ZNF107; ZBTB11; HEYL; TTF2; UBC; TTF1; SOX5; MYOD1; XRCC6; CTNNB1; MAPK14; BAMBI; PPP1R15A; NEDD4L; STAMBP; YAP1; AXIN1; TP5
Blocking Peptide:
For anti-SMAD7 (ARP32008_P050) antibody is Catalog # AAP32008
Datasheets/Manuals:
Printable datasheet for anti-SMAD7 (ARP32008_P050) antibody
Target Reference:
Komuro,A., et al., (2004) Oncogene 23 (41), 6914-6923

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