Size:400ul
$329.00
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OAAB09840
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SMAD3 Antibody - middle region (OAAB09840)

Catalog#: OAAB09840
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species Reactivity Human, Mouse, Pig, Rat
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality Polyclonal
Isotype Ig
Host Rabbit
Application WB, IF, IHC
Additional Information Precautions: SMAD3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
:: Function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator
:: Cellular Location: Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Co-localizes with LEMD3 at the nucleus inner membrane MAPK-mediated phosphorylation appears to have no
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-101154 from Santa Cruz Biotechnology.
Immunogen This SMAD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the Central region of human SMAD3.
Predicted Homology Based on Immunogen Sequence Human; Mouse; Pig; Rat
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals Printable datasheet for OAAB09840
Application Info WB: 1:1000
IF: 1:10~50
IHC-P: 1:10~50
Gene Symbol SMAD3
Alias Symbols SMAD3, MADH3, Mothers against decapentaplegic homolog 3, JV15-2, SMAD family member 3
NCBI Gene Id 4088
Protein Name Mothers against decapentaplegic homolog 3
Description of Target Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Swissprot Id P84022
Protein Accession # NP_001138574.1
Molecular Weight 48081 Da
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express SMAD3.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express SMAD3.
  1. What is the species homology for "SMAD3 Antibody - middle region (OAAB09840)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Pig, Rat".

  2. How long will it take to receive "SMAD3 Antibody - middle region (OAAB09840)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "SMAD3 Antibody - middle region (OAAB09840)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SMAD3 Antibody - middle region (OAAB09840)"?

    This target may also be called "SMAD3, MADH3, Mothers against decapentaplegic homolog 3, JV15-2, SMAD family member 3" in publications.

  5. What is the shipping cost for "SMAD3 Antibody - middle region (OAAB09840)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SMAD3 Antibody - middle region (OAAB09840)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SMAD3 Antibody - middle region (OAAB09840)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "48081 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SMAD3 Antibody - middle region (OAAB09840)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "SMAD3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SMAD3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SMAD3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SMAD3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SMAD3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SMAD3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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