SMAD2 Protein (OPPA01845)

Catalog No: OPPA01845 (Formerly GWB-F1FB7D)

Size:2UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid 20mM Tris-HCl (pH 8) and 100mM NaCl
• Host: E. Coli
• Reconstitution and Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen, at -20°C for longer periods of time. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze/thaw cycles.
• Concentration: Varies by lot. See vial for concentration.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Peptide Sequence: MGSSHHHHHH SSGLVPRGSH MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE LEKAITTQNC NTKCVTIPSTCSEIWGLSTP NTIDQWDTTG LYSFSEQTRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLVPRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYYELNQRVGETF HASQPSLTVD GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP NCNQRYGWHP ATVCKIPPGCNLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS.
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: SMAD2
• Alias Symbols: JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2
• NCBI Gene Id: 4087
• Protein Name: Mothers against decapentaplegic homolog 2
• Description of Target: SMAD2 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated SMAD2 is then able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. TGF-beta 1 acts on adjacent stromal cells to turn on SMAD2 signalling that could lead to stromal decidualization. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells.
• Uniprot ID: Q15796
• Protein Accession #: NP_001003652.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 54 kDa