SLPI Recombinant Protein (OPCD07056)

Catalog No: OPCD07056

SLPI Recombinant Protein (OPCD07056) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Lyophilized PBS (pH 7.4) containing 0.01% SKL, 5% Trehalose
• Host: E.coli
• Conjugation: Unconjugated
• Application: Ctrl (+), SDS-PAGE, WB
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Pro20-Met131
  Subcellular Location: Secreted
  Isoelectric Point: 8.7
• Reconstitution and Storage: Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/ml. Do not vortex. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Avoid repeated freeze/thaw cycles.
• Concentration: 80 ug/mL (prior to lyoph)
• Purity: > 80%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Slpi
• Gene Full Name: secretory leukocyte peptidase inhibitor
• Alias Symbols: ALP;antileukoproteinase;secretory leukocyte protease inhibitor.
• NCBI Gene Id: 20568
• Protein Name: Antileukoproteinase
• Description of Target: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:9126337). Modulates the innate immune response after bacterial infection (PubMed:12615907). Contributes to regulate the inflammatory and immune responses to the intracellular parasite L.major (PubMed:25030421). Down-regulates responses to bacterial lipopolysaccharide (LPS) (PubMed:9039268, PubMed:12615907, PubMed:25030421). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:11017147, PubMed:12615907). Has antimicrobial activity against mycobacteria, but not against salmonella (PubMed:18322212). Contributes to normal resistance against infection by M.tuberculosis (PubMed:18322212). Required for normal resistance to L.major (PubMed:25030421). Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (PubMed:11017147, PubMed:25030421). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity).
• Uniprot ID: P97430
• Protein Accession #: NP_035544.1
• Nucleotide Accession #: NM_011414.3
• Protein Size (# AA): Pro20~Met131
• Molecular Weight: 19 kDa