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SLC5A5 antibody - middle region (ARP43752_P050)

100 ul
$319.00
In Stock

Conjugation Options

ARP43752_P050-FITC Conjugated

ARP43752_P050-HRP Conjugated

ARP43752_P050-Biotin Conjugated

Gene Symbol:
SLC5A5
NCBI Gene Id:
6528
Official Gene Full Name:
Solute carrier family 5 (sodium iodide symporter), member 5
Protein Name:
Sodium/iodide cotransporter
Swissprot Id:
Q92911
Protein Accession #:
NP_000444
Nucleotide Accession #:
NM_000453
Alias Symbols:
NIS, TDH1
Replacement Item:
This antibody may replace item sc-34189 from Santa Cruz Biotechnology.
Description of Target:
The sodium-iodide symporter (NIS, or SLC5A5) is a key plasma membrane protein that mediates active I- uptake in thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ per I-. In thyroid, NIS-mediated I- uptake is the first step in the biosynthesis of iodine-containing thyroid hormones.The sodium-iodide symporter (NIS, or SLC5A5) is a key plasma membrane protein that mediates active I- uptake in thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ per I-. In thyroid, NIS-mediated I- uptake is the first step in the biosynthesis of iodine-containing thyroid hormones (Dohan et al., 2007 [PubMed 18077370]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
643
Molecular Weight:
69kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SLC5A5.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SLC5A5.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human SLC5A5
Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human: 100%
Complete computational species homology data:
Anti-SLC5A5 (ARP43752_P050)
Peptide Sequence:
Synthetic peptide located within the following region: PSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRP
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
ERBB2IP; SLC5A5;
Blocking Peptide:
For anti-SLC5A5 (ARP43752_P050) antibody is Catalog # AAP43752 (Previous Catalog # AAPP25342)
Datasheets/Manuals:
Printable datasheet for anti-SLC5A5 (ARP43752_P050) antibody
Sample Type Confirmation:

SLC5A5 is supported by BioGPS gene expression data to be expressed in HEK293T

Target Reference:
Fenton,M.S., (2008) Endocrinology 149 (5), 2592-2606
Publications:

Liu, F. et al. Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex. PLoS One 7, e38589 (2012). WB, Human 22719903

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