Catalog No: OPCD07036
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OPCD07036
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Datasheets/ManualsPrintable datasheet for SLC3A2 Recombinant Protein (OPCD07036)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Ile285-Gln522
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His and GST Tag
Gene SymbolSlc3a2
Gene Full Namesolute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Alias Symbols4F2;4F2 cell-surface antigen heavy chain;4F2HC;AI314110;antigen identified by monoclonal antibodies 4F2;Cd98;CD98 antigen;CD98 heavy chain;Ly-1;Ly10;Ly-10;Ly-m1;Ly-m10;Mdu1;Mgp-2h;Mgp-2hc;NACAE;solute carrier family 3 member 2;type II transmembrane protein.
NCBI Gene Id17254
Protein Name4F2 cell-surface antigen heavy chain
Description of TargetRequired for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. When associated with LAPTM4B, recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (By similarity).
Uniprot IDP10852
Protein Accession #NP_001154885.1
Nucleotide Accession #NM_001161413.1
Protein Size (# AA)Ile285~Gln521
Molecular Weight56kDa
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