Catalog No: OABB01918
Size:100UG
Price: $432.00
SKU
OABB01918
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Datasheets/ManualsPrintable datasheet for SLC2A1 Antibody (OABB01918)
Product Info
Tested Species ReactivityHuman, Mouse, Rat
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
ClonalityPolyclonal
ClonePolyclonal
IsotypeRabbit IgG
HostRabbit
ApplicationFlow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Frozen|Western blot
Additional InformationNotes: WB: The detection limit for SLC2A1 is approximately 0.1ng/lane under reducing conditions.
Tested Species: In-house tested species with positive results.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
::Background: GLUT1, also known as SLC2A1, is a major glucose transporter in the mammalian blood-brain barrier whose gene is mapped to 1p35-p31.3 and contains 10 exons. It is present at high levels in primate erythrocytes and brain endothelial cells. Not only can transport dehydroascorbic acid (the oxidized form of vitamin C) into the brain, GLUT1 is also likely to contribute to HTLV-associated disorders through interacting with HTLV envelope glycoproteins. Functionally, GLUT1 deficiency causes a decrease in embryonic glucose uptake and apoptosis, which may be involved in diabetic embryopathy, by contrast, an increased expression of GLUT1 in some malignant tumors may suggest a role for glucose-derivative tracers to detect in vivo thyroid cancer metastases by positron-emission tomography scanning.
Reconstitution and Storage2°C to 8°C|-20°C
ImmunogenE.coli-derived human SLC2A1 recombinant protein (Position: R92-V492). Human SLC2A1 shares 98% and 98.3% amino acid (aa) sequence identity with mouse and rat SLC2A1, respectively.
PurificationAffinity Purified
Peptide SequenceRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
Concentration500 ug/ml
SpecificityNo cross reactivity with other proteins.
Application InfoWestern blot: 0.1-0.5 ug/ml: Human
Immunohistochemistry (Paraffin-embedded Section): 0.5-1 ug/ml: Human, Mouse, Rat: By Heat
Immunohistochemistry (Frozen Section): 0.5-1 ug/ml: Human
Immunocytochemistry/Immunofluorescence: 2 ug/ml: Human
Flow Cytometry: 1-3 ug/1x10^6 cells: Human
Reference1. Agus, D. B.; Gambhir, S. S.; Pardridge, W. M.; Spielholz, C.; Baselga, J.; Vera, J. C.; Golde, D. W. : Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J. Clin. Invest. 100: 2842-2848, 1997.
2. Heilig, C. W.; Saunders, T.; Brosius, F. C., III; Moley, K.; Heilig, K.; Baggs, R.; Guo, L.; Conner, D. : Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy. Proc. Nat. Acad. Sci. 100: 15613-15618, 2003.
3. Lazar, V.; Bidart, J.-M.; Caillou, B.; Mahe, C.; Lacroix, L.; Filetti, S.; Schlumberger, M. : Expression of the Na(+)/I(-) symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J. Clin. Endocr. Metab. 84: 3228-3234, 1999.
4. Manel, N.; Kim, F. J.; Kinet, S.; Taylor, N.; Sitbon, M.; Battini, J.-L. : The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 115: 449-459, 2003.
Storage BufferEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
DescriptionRabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 1(SLC2A1) detection. Tested with WB, IHC-P, IHC-F, ICC/IF, FCM in Human;Mouse;Rat.
Gene SymbolSLC2A1
Gene Full Namesolute carrier family 2 member 1
Alias Symbolschoreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity);CSE;DYT17;DYT18;DYT9;EIG12;glucose transporter type 1, erythrocyte/brain;GLUT;GLUT1;GLUT-1;GLUT1DS;hepG2 glucose transporter;HTLVR;human T-cell leukemia virus (I and II) receptor;PED;receptor for HTLV-1 and HTLV-2;SDCHCN;solute carrier family 2 (facilitated glucose transporter), member 1;solute carrier family 2, facilitated glucose transporter member 1.
NCBI Gene Id6513
Protein NameSolute carrier family 2, facilitated glucose transporter member 1
Description of TargetFacilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
Uniprot IDP11166
Molecular Weight54084 MW
  1. What is the species homology for "SLC2A1 Antibody (OABB01918)"?

    The tested species reactivity for this item is "Human, Mouse, Rat". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "SLC2A1 Antibody (OABB01918)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "SLC2A1 Antibody (OABB01918)" provided in?

    This item is provided in "Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SLC2A1 Antibody (OABB01918)"?

    This target may also be called "choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity);CSE;DYT17;DYT18;DYT9;EIG12;glucose transporter type 1, erythrocyte/brain;GLUT;GLUT1;GLUT-1;GLUT1DS;hepG2 glucose transporter;HTLVR;human T-cell leukemia virus (I and II) receptor;PED;receptor for HTLV-1 and HTLV-2;SDCHCN;solute carrier family 2 (facilitated glucose transporter), member 1;solute carrier family 2, facilitated glucose transporter member 1." in publications.

  5. What is the shipping cost for "SLC2A1 Antibody (OABB01918)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SLC2A1 Antibody (OABB01918)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SLC2A1 Antibody (OABB01918)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "54084 MW".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SLC2A1 Antibody (OABB01918)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SLC2A1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SLC2A1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SLC2A1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SLC2A1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SLC2A1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SLC2A1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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