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Catalog No: OAAB05828
Size:400ul
Price: $438.00
SKU
OAAB05828
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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Datasheets/ManualsPrintable datasheet for anti-SLC22A6 antibody - OAAB05828
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid.PBS with 0.09% (W/V) sodium azide
ClonalityPolyclonal
IsotypeRabbit Ig
HostRabbit
ApplicationFC, IHC-P, WB
Additional InformationFunction: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.
::Cellular Location: Cell membrane; Multi-pass membrane protein
Tissue Location: Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule.
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis SLC22A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513-541 amino acids from the C-terminal region of human SLC22A6.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Application InfoWB: 1:1,000
IHC-P: 1:10~50
FC: 1:10~50
Optimal dilutions should be determined by the end user.
Other Applications Image 1 DataSLC22A6 Antibody (C-Term) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ReferenceHong,M., et.al, J. Pharmacol. Exp. Ther. 332 (2), 650-658 (2010)
Shin,H.J., et.al, Clin. Chim. Acta 411 (1-2), 99-105 (2010)
Gene SymbolSLC22A6
Alias SymbolsOAT1, PAHT, HOAT1, ROAT1
NCBI Gene Id9356
Description of TargetThe protein is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane.
Uniprot IDQ4U2R8
Protein Accession #NP_004781
Molecular Weight62 kDa
  1. What is the species homology for "SLC22A6 Antibody - C-terminal region (OAAB05828)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "SLC22A6 Antibody - C-terminal region (OAAB05828)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "SLC22A6 Antibody - C-terminal region (OAAB05828)" provided in?

    This item is provided in "Liquid.PBS with 0.09% (W/V) sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SLC22A6 Antibody - C-terminal region (OAAB05828)"?

    This target may also be called "OAT1, PAHT, HOAT1, ROAT1" in publications.

  5. What is the shipping cost for "SLC22A6 Antibody - C-terminal region (OAAB05828)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SLC22A6 Antibody - C-terminal region (OAAB05828)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SLC22A6 Antibody - C-terminal region (OAAB05828)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "62 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SLC22A6 Antibody - C-terminal region (OAAB05828)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SLC22A6"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SLC22A6"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SLC22A6"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SLC22A6"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SLC22A6"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SLC22A6"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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