SLC22A4 Antibody - C-terminal region (OAAB03385)

Catalog No: OAAB03385 (Formerly GWB-Y13ZBD)

Size:400ul

SLC22A4 Antibody (C-term) western blot analysis in Hela,K562 cell lysates (35ug/lane).This demonstrates the SLC22A4 antibody detected the SLC22A4 protein (arrow).

SLC22A4 is strongly supported by BioGPS gene expression data to be expressed in Hela

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB
• Additional Information: Function: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
  Cellular Location: Membrane; Multi-pass membrane protein.
  Tissue Location: Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This SLC22A4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 514-542 amino acids from the C-terminal region of human SLC22A4.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Sample Type Confirmation:

  SLC22A4 is strongly supported by BioGPS gene expression data to be expressed in Hela

• Application Info: WB: 1:1000
• Publications:

  Salomon, J. J. et al. The Cell Line NCl-H441 Is a Useful in Vitro Model for Transport Studies of Human Distal Lung Epithelial Barrier. Mol. Pharm. (2014). doi:10.1021/mp4006535 24524365

Target Info

• Gene Symbol: SLC22A4
• Alias Symbols: OCTN1, DFNB60
• NCBI Gene Id: 6583
• Protein Name: Solute carrier family 22 member 4
• Uniprot ID: Q9H015
• Protein Accession #: NP_003050.2
• Molecular Weight: 62155 Da