SLC12A2 Antibody - N-terminal region (OABB01332)

Catalog No: OABB01332

Size:100UG

Anti-NKCC1 antibody, OABB01332, Western blotting
WB: HELA Cell Lysate

Anti-NKCC1 antibody, OABB01332, IHC(F)
IHC(F): Rat Intestine Tissue

Anti-NKCC1 antibody, OABB01332, IHC(P)
IHC(P): Human Intestinal Cancer Tissue

Anti-NKCC1 antibody, OABB01332, IHC(P)
IHC(P): Rat Intestine Tissue

Product Info

• Tested Species Reactivity: Human, Rat
• Predicted Species Reactivity: Hamster|Human|Mouse|Rat
• Product Format: Lyophilized. Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
• Clonality: Polyclonal
• Clone: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: Immunohistochemistry|Western blot
• Additional Information: Notes: Tested Species: In-house tested species with positive results.
  Predicted Species: Species predicted to be fit for the product based on sequence similarities.
  By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
  Other applications have not been tested.
  Optimal dilutions should be determined by end users.
  
  Background: Solute carrier family 12(sodium/potassium/chloride transporters), member 2, also known as NKCC1, is widely distributed throughout the body, especially in organs that secrete fluids, called exocrine glands. By fluorescence in situ hybridization, this gene is mapped to chromosome 5q23.3. The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Polypeptide
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Mouse
• Concentration: 500 ug/ml
• Specificity: No cross reactivity with other proteins.
• Dilution: Optimal dilutions should be determined by end users.
• Intended Use: For research use only. Not for diagnostic and clinical use.
• Application Info: Western blot: 0.1-0.5 ug/ml: Human: Mouse, Rat
  Immunohistochemistry (Paraffin-embedded Section): 0.5-1 ug/ml: Human, Rat: Mouse: By Heat
  Immunohistochemistry (Frozen Section): 0.5-1 ug/ml: Rat: Human, Mouse
• Storage Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Publications:

  Impaired glucose tolerance, glucagon, and insulin responses in mice lacking the loop diuretic-sensitive Nkcc2a transporter. Am J Physiol Cell Physiol. 317, C843-C856 (2019). 31365295

• Description:
  View product citations for SLC12A2 Antibody - N-terminal region (OABB01332) on CiteAb

Target Info

• Gene Symbol: SLC12A2
• Gene Full Name: solute carrier family 12 member 2
• Alias Symbols: basolateral Na-K-Cl symporter;BSC;BSC2;bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1;bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2;KILQS;NKCC1;PPP1R141;protein phosphatase 1, regulatory subunit 141;solute carrier family 12 (sodium/potassium/chloride transporter), member 2;solute carrier family 12 (sodium/potassium/chloride transporters), member 2;solute carrier family 12 member 2.
• NCBI Gene Id: 6558
• Protein Name: Solute carrier family 12 member 2
• Description of Target: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
• Uniprot ID: P55011
• Molecular Weight: 131447 MW