SLAMF7 Antibody (OABF01020)

Catalog No: OABF01020

Size:100UL

Formalin-fixed and paraffin embedded mouse stomach labeled with Anti-SLAMF7/CD319/CS1 Polyclonal Antibody, Unconjugated (OABF01020) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed and paraffin embedded mouse intestine labeled with Anti-SLAMF7/CD319/CS1 Polyclonal Antibody, Unconjugated (OABF01020) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Predicted Species Reactivity: Bovine|Human|Mouse|Rat
• Product Format: Liquid. Aqueous buffered solution with 1% BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Western blot
• Additional Information: Subcellular Location: Extracellular.
  
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human SLAMF7
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Intended Use: For research use only. Not intended for diagnostic or therapeutic use.
• Application Info: WB: 1:100 - 1000
  IHC-P: 1:100 - 500

Target Info

• Gene Symbol: SLAMF7
• Gene Full Name: SLAM family member 7
• Alias Symbols: 19A;19A24 protein;CD2 subset 1;CD2-like receptor activating cytotoxic cells;CD2-like receptor-activating cytotoxic cells;CD319;CRACC;CS1;membrane protein FOAP-12;Novel Ly9;novel LY9 (lymphocyte antigen 9) like protein;protein 19A;SLAM family member 7.
• NCBI Gene Id: 57823
• Protein Name: SLAM family member 7
• Description of Target: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
• Uniprot ID: Q9NQ25