SLA2 Antibody - middle region (OAAB22126)

Catalog No: OAAB22126

Size:400ul

SLA2 Antibody - Middle Region (OAAB22126) at 1:2000 dilution + K562 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size: 29 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

All lanes: SLA2 Antibody - Middle Region (OAAB22126) at 1:2000 dilution Lane 1:mouse liver lysates Lane 2: human spleen lysates Lane 3: K562 whole cell lysates Lane 4: MOLT-4 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size: 29 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Clone: RB53789
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB
• Additional Information: Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This SLA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 138-169 amino acids from the Central region of human SLA2.
• Purification: Protein A column purification, followed by peptide affinity purification
• Predicted Homology Based on Immunogen Sequence: Human, Mouse
• Concentration: 500 ug/mL
• Preservative: 0.09% Sodium Azide
• Formulation: Purified polyclonal antibody, supplied in PBS with 0.09% sodium azide.
• Application Info: WB: 1:2000
• Reference: Holland S.J.,et al.J. Exp. Med. 194:1263-1276(2001).
  Loreto M.P.,et al.Oncogene 22:266-273(2003).
  Ota T.,et al.Nat. Genet. 36:40-45(2004).
  Deloukas P.,et al.Nature 414:865-871(2001).
  Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
  

Target Info

• Gene Symbol: SLA2
• Gene Full Name: Src-like-adaptor 2
• Alias Symbols: MARS, SLAP2, SLAP-2, C20orf156
• NCBI Gene Id: 84174
• Description of Target: This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.
• Uniprot ID: Q9H6Q3
• Protein Accession #: NP_115590.1
• Nucleotide Accession #: NM_032214.3
• Molecular Weight: 29 kDa