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SKP2 Antibody - middle region (OAAB05096)

400ul
$390.00
In Stock
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Gene Symbol:
SKP2
NCBI Gene Id:
6502
Protein Name:
S-phase kinase-associated protein 2
Swissprot Id:
Q13309
Protein Accession #:
NP_001230049.1
Alias Symbols:
S-phase kinase-associated protein 2, F-box protein Skp2, Cyclin A/CDK2-associated protein p45, p45skp2, F-box/LRR-repeat protein 1, FBXL1, SKP2
Replacement Item:
This antibody may replace item sc-123570 from Santa Cruz Biotechnology.
Molecular Weight:
47761 Da
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB, FC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SKP2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SKP2.
Immunogen:
This SKP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human SKP2.
Predicted Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for anti-SKP2 antibody - OAAB05096
Sample Type Confirmation:

SKP2 is strongly supported by BioGPS gene expression data to be expressed in Hela

Isotype:
Rabbit Ig
Application Info:
WB: 1:1000
FC: 1:10~50
Additional Information:
Function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
:::
Cellular Location: Cytoplasm. Nucleus.

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