Size:400ul
$329.00
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SKU
OAAB05096
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SKP2 Antibody - middle region (OAAB05096)

Catalog#: OAAB05096
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species Reactivity Human
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Clonality Polyclonal
Isotype Rabbit Ig
Host Rabbit
Application WB, FC
Additional Information Function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
:: Cellular Location: Cytoplasm. Nucleus.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-123570 from Santa Cruz Biotechnology.
Immunogen This SKP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human SKP2.
Predicted Homology Based on Immunogen Sequence Human
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals Printable datasheet for anti-SKP2 antibody - OAAB05096
Sample Type Confirmation

SKP2 is strongly supported by BioGPS gene expression data to be expressed in Hela

Application Info WB: 1:1000
FC: 1:10~50
Other Applications Image 1 Data Flow cytometric analysis of hela cells using SKP2 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Gene Symbol SKP2
Alias Symbols S-phase kinase-associated protein 2, F-box protein Skp2, Cyclin A/CDK2-associated protein p45, p45skp2, F-box/LRR-repeat protein 1, FBXL1, SKP2
NCBI Gene Id 6502
Protein Name S-phase kinase-associated protein 2
Swissprot Id Q13309
Protein Accession # NP_001230049.1
Molecular Weight 47761 Da
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express SKP2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express SKP2.
  1. What is the species homology for "SKP2 Antibody - middle region (OAAB05096)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "SKP2 Antibody - middle region (OAAB05096)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "SKP2 Antibody - middle region (OAAB05096)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SKP2 Antibody - middle region (OAAB05096)"?

    This target may also be called "S-phase kinase-associated protein 2, F-box protein Skp2, Cyclin A/CDK2-associated protein p45, p45skp2, F-box/LRR-repeat protein 1, FBXL1, SKP2" in publications.

  5. What is the shipping cost for "SKP2 Antibody - middle region (OAAB05096)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SKP2 Antibody - middle region (OAAB05096)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SKP2 Antibody - middle region (OAAB05096)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "47761 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SKP2 Antibody - middle region (OAAB05096)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "SKP2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SKP2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SKP2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SKP2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SKP2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SKP2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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