SIRT7 Antibody - middlel region (ARP89637_P050)

Catalog No: ARP89637_P050

Host: Rabbit
Target Name: SIRT7
Sample Tissue: Mouse Brain lysates
Antibody Dilution: 1ug/ml

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse SIRT7
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: RQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVC
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-SIRT7 (ARP89637_P050) antibody is Catalog # AAP89637

Target Info

• Gene Symbol: SIRT7
• Gene Full Name: sirtuin 7
• NCBI Gene Id: 209011
• Protein Name: NAD-dependent protein deacetylase sirtuin-7
• Description of Target: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions (By similarity). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
• Uniprot ID: Q8BKJ9
• Protein Accession #: NP_694696.2
• Nucleotide Accession #: NM_153056.2
• Protein Size (# AA): 402
• Molecular Weight: 45 kDa