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Catalog No: OPCD06992
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OPCD06992
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Datasheets/ManualsPrintable datasheet for SIRPA Recombinant Protein (OPCD06992)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Thr56-Arg296
::Subcellular Location: Membrane; Single-pa
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolSirpa
Gene Full Namesignal-regulatory protein alpha
Alias SymbolsAI835480;Bi;Bit;brain Ig-like molecule with tyrosine-based activation motifs;brain immunological-like with tyrosine-based motifs;CD172;CD172 antigen-like family member A;CD172a;Idd13.2;inhibitory receptor SHPS-1;mSIRP-alpha1;myD-1 antigen;P8;P84;protein tyrosine phosphatase, non-receptor type substrate 1;Pt;Ptpns1;SHP;SHP substrate 1;SHP-1;SHPS-1;signal-regulatory protein alpha-1;SIRP;sirp-alpha-1;tyrosine-protein phosphatase non-receptor type substrate 1.
NCBI Gene Id19261
Protein NameTyrosine-protein phosphatase non-receptor type substrate 1
Description of TargetImmunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity).
Uniprot IDP97797
Protein Accession #NP_001171118.1
Nucleotide Accession #NM_001177647.2
Protein Size (# AA)Thr56~Arg296
Molecular Weight32kDa
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