Aviva Systems Biology will be closed in observance of Good Friday 3/29/2024. If you are in need of any assistance please email info@avivasysbio.com

Catalog No: OPCD06991
Price: $0.00
SKU
OPCD06991
Availability: Domestic: within 1-2 weeks delivery | International: within 1-2 weeks delivery
Bulk
Order
Aviva's
Satisfaction
Guarantee
Contact Us:
Shipping Info:
  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.
Datasheets/ManualsPrintable datasheet for SIRPA Recombinant Protein (OPCD06991)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Residues: Ser105-Arg324
Subcellular Location: Membrane
Isoelectric Point: 7.8
Reconstitution and Storage2°C to 8°C|-80°C
Concentration300 ug/mL (prior to lyoph)
Purity>95%
SourceE.coli
TagN-terminal His and GST Tag
Gene SymbolSIRPA
Gene Full Namesignal regulatory protein alpha
Alias SymbolsBIT;Brain Ig-like molecule with tyrosine-based activation motifs;brain-immunoglobulin-like molecule with tyrosine-based activation motifs;CD172 antigen-like family member A;CD172A;inhibitory receptor SHPS-1;macrophage fusion receptor;MFR;MYD-1;myd-1 antigen;P84;PTPNS1;SHPS1;Signal-regulatory protein alpha-1;Signal-regulatory protein alpha-2;Signal-regulatory protein alpha-3;SIRP;tyrosine phosphatase SHP substrate 1;tyrosine-protein phosphatase non-receptor type substrate 1.
NCBI Gene Id140885
Protein NameTyrosine-protein phosphatase non-receptor type substrate 1
Description of TargetImmunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Uniprot IDP78324
Protein Accession #NP_001035111.1
Nucleotide Accession #NM_001040022.1
Protein Size (# AA)Ser105~Arg324
Molecular Weight60kDa
Write Your Own Review
You're reviewing:SIRPA Recombinant Protein (OPCD06991)
Your Rating
We found other products you might like!