SIRPA Recombinant Protein (OPCD06990)

Catalog No: OPCD06990

SIRPA Recombinant Protein (OPCD06990) using SDS-PAGE

SIRPA Recombinant Protein (OPCD06990) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Asp116-Asp308
  Subcellular Location: Membrane; Single-pass type I membrane prote
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Sirpa
• Gene Full Name: signal-regulatory protein alpha
• Alias Symbols: Bit;brain Ig-like molecule with tyrosine-based activation motifs;Brain immunoglobulin like protein with tyrosine - based activation motifs;CD172 antigen-like family member A;inhibitory receptor SHPS-1;macrophage fusion receptor;macrophage membrane protein MFP150;Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1);Ptpns1;SHP substrate 1;SHPS-1;signal-regulatory protein alpha-1;sirp-alpha-1;tyrosine-protein phosphatase non-receptor type substrate 1.
• NCBI Gene Id: 25528
• Protein Name: Tyrosine-protein phosphatase non-receptor type substrate 1
• Description of Target: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. May play a role in the release of nitric oxide by macrophages (By similarity).
• Uniprot ID: P97710
• Protein Accession #: NP_037148.2
• Nucleotide Accession #: NM_013016.2
• Protein Size (# AA): Asp116~Asp308
• Molecular Weight: 27kDa