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SIAH1 Antibody (OAEB01633)

100 ug
$349.00
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Gene Symbol:
SIAH1
NCBI Gene Id:
6477
Protein Name:
E3 ubiquitin-protein ligase SIAH1
Swissprot Id:
Q8IUQ4
Protein Accession #:
NP_003022.3
Replacement Item:
This antibody may replace item sc-22765 from Santa Cruz Biotechnology.
Host:
Goat
Clonality:
Polyclonal
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SIAH1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SIAH1.
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Human, Mouse, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 86%; Rat: 100%; Zebrafish: 100%
Complete computational species homology data:
SIAH1 Antibody (OAEB01633)
Peptide Sequence:
SRQTATALPTGTSKC
Product Format:
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Reconstitution and Storage:
Aliquot and store at -20C. Minimize freezing and thawing.
Datasheets/Manuals:
Printable datasheet for anti-SIAH1 antibody - OAEB01633
Purity:
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Application Info:
Peptide ELISA: antibody detection limit dilution 1:32000.
Western Blot: Approx 28+30kDa bands observed in Human Liver lysates (calculated MW of 31.1kDa and 34.6kDa according to NP_003022.3 and NP_001006611.1). Recommended concentration: 0.1-0.3ug/ml.
:::
Description: This product is expected to recognize both reported isoforms (according to NP_003022.3; NP_001006611.1)
Target Reference:
* Guigon CJ, Zhao L, Lu C, Willingham MC, Cheng SY.; Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor.; Mol Cell Biol. 2008 Jul;28(14):4598-608.; Pubmed 18474620
* Groenman F, Rutter M, Caniggia I, Tibboel D, Post M.; Hypoxia-inducible factors in the first trimester human lung.; J Histochem Cytochem. 2007 Apr;55(4):355-63.; Pubmed 17189520
* Iwai A, Marusawa H, Matsuzawa S, Fukushima T, Hijikata M, Reed JC, Shimotohno; K, Chiba T.; Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner.; Oncogene. 2004 Sep 30;23(45):7593-600.; Pubmed 15326481
* Susini L, Passer BJ, Amzallag-Elbaz N, Juven-Gershon T, Prieur S, Privat N, Tuynder M, Gendron MC, Israel A, Amson R, Oren M, Telerman A.; Siah-1 binds and regulates the function of Numb.; Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15067-72.; Pubmed 11752454

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