SHOC2 Antibody : FITC (OAPB00903-FITC)

Catalog No: OAPB00903-FITC

Size:0.1 mg

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: ELISA, WB, IHC
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen for anti-SHOC2 antibody: antibody was raised against a 21 amino acid peptide near the amino terminus of human SHOC2.
• Purification: Affinity chromatography purified via peptide column
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-SHOC2 antibody is Catalog # OEPB03025
• Application Info: SHOC2 antibody can be used for detection of Shoc2 by Western blot at 1-2 ug/ml. (Optimal dilution should be determined by user)
• Reference: Selfors LM, Schutzman JL, Borland CZ, et al. Soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. Proc. Natl. Acad. Sci. USA1998; 95:6903-8.;Sieburth DS, Sun Q, and Han M. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell1998; 94:119–130.;Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, et al. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol. Cell2006; 22:217-30.;Li W, Han M, and Guan KL. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev.2000; 14:895–900.

Target Info

• Gene Symbol: SHOC2
• Alias Symbols: SOC2, SUR8, NSLH1, SIAA0862
• NCBI Gene Id: 8036
• Protein Name: Leucine-rich repeat protein SHOC-2
• Description of Target: Ras-binding protein Sur-8
• Uniprot ID: Q9UQ13