SHANK2 Antibody - C-terminal region (ARP64053_P050)

Catalog No: ARP64053_P050

WB Suggested Anti-SHANK2 Antibody
Titration: 1.0 ug/ml
Positive Control: ACHN Whole Cell

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 86%; Dog: 79%; Guinea Pig: 86%; Human: 100%; Mouse: 77%; Rat: 93%
• Peptide Sequence: Synthetic peptide located within the following region: DLVKQKKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDA
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-SHANK2 (ARP64053_P050) antibody is Catalog # AAP64053

Target Info

• Gene Symbol: SHANK2
• Gene Full Name: SH3 and multiple ankyrin repeat domains 2
• Alias Symbols: SHANK, AUTS17, CORTBP1, CTTNBP1, ProSAP1, SPANK-3
• NCBI Gene Id: 22941
• Description of Target: This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.
• Uniprot ID: Q9UPX8
• Protein Accession #: EAW74775
• Nucleotide Accession #: NM_012309
• Protein Size (# AA): 1153
• Molecular Weight: 126kDa
• Protein Interactions: SHARPIN; NLK; LPHN1; DLGAP1; LPHN2; ARHGEF7; BAIAP2; DLG4; BAI2; DNM2; SSTR2; SLC9A3; CTTN; DLGAP3; DLGAP4; DLGAP2; DYNLL2; DYNLL1; MYO5A;