Aviva Systems Biology will be closed in observance of Good Friday 3/29/2024. If you are in need of any assistance please email info@avivasysbio.com

Catalog No: OPCD06946
Price: $0.00
SKU
OPCD06946
Availability: Domestic: within 1-2 weeks delivery | International: within 1-2 weeks delivery
Bulk
Order
Aviva's
Satisfaction
Guarantee
Contact Us:
Shipping Info:
  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.

SH2D1A Recombinant Protein (OPCD06946)

Datasheets/ManualsPrintable datasheet for SH2D1A Recombinant Protein (OPCD06946)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Lys18-Gly115
::Subcellular Location: Cytoplasm
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolSh2d1a
Gene Full NameSH2 domain containing 1A
Alias SymbolsDuncan disease homolog;Gm686;SAP;SH2 domain protein 1A;SH2 domain-containing protein 1A;signaling lymphocytic activation molecule-associated protein;T-cell signal transduction molecule SAP.
NCBI Gene Id20400
Protein NameSH2 domain-containing protein 1A
Description of TargetCytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (By similarity). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions (PubMed:22683124). Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation (PubMed:19648922). In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (PubMed:22683124). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Uniprot IDO88890
Protein Accession #NP_001300617.1
Nucleotide Accession #NM_001313688.1
Protein Size (# AA)Lys18~Gly115
Molecular Weight16kDa
Write Your Own Review
You're reviewing:SH2D1A Recombinant Protein (OPCD06946)
Your Rating