SGPP2 Antibody - N-terminal region (OAAB13773)

Catalog No: OAAB13773

Size:400ul

SGPP2 Antibody (N-term) (Cat. # OAAB13773) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SGPP2 antibody detected the SGPP2 protein (arrow).

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
  Function: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.
  Cellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein
  Tissue Location: Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This SGPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-33 amino acids from the N-terminal region of human SGPP2.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: 0.44 mg/ml
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: SGPP2
• Alias Symbols: SPP2, SPPase2
• NCBI Gene Id: 130367
• Protein Name: Sphingosine-1-phosphate phosphatase 2
• Description of Target: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP2 catalyzes the degradation of S1P.
• Uniprot ID: Q8IWX5
• Protein Accession #: NP_689599.2
• Molecular Weight: 45 kDa