SERPINE1 Protein (OPPA01523)

Catalog No: OPPA01523 (Formerly GWB-1F5E08)

Size:2ug

Product Info

• Product Format: 0.05M sodium phosphate 0.1M NaCl and 1mM EDTA (pH 6.6). Physical appearance: Sterile Filtered clear colorless solution.
  Product Introduction: Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator(tPA) and urokinase(uPA), the activators of plasminogenand hence fibrinolysis(the physiological breakdown of blood clots). It is a serine protease inhibitor(serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2(PAI-2) is secreted by the placentaand only present in significant amounts during pregnancy. In addition, protease nexinacts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.
  Product Description: Constitutively active human plasminogen activator inhibitor 1, stable mutant 14-1B having a Molecular mass of 43 kDa. This human form of SERPINE1 contains the following four mutations: K154T, Q139L, M354I and N150H. These mutations combine to confer great stability to the otherwise labile molecule essentially locking it into the active conformation. The SERPINE1 is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: Human SERPINE1 although stable at 8C celsius for 1 week, should be stored desiccated below -18C.
• Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Target Info

• Gene Symbol: SERPINE1
• Alias Symbols: PAI, PAI1, PAI-1, PLANH1
• NCBI Gene Id: 5054
• Protein Name: Plasminogen activator inhibitor 1
• Description of Target: Human Plasminogen Activator Inhibitor-1
• Uniprot ID: P05121
• Protein Accession #: NP_000593.1