SERPINE1 Antibody (OABF01707)

Catalog No: OABF01707

Size:100UL

Formalin-fixed and paraffin-embedded mouse intestine labeled with Anti-PAI1/PLANH1/Serpine 1 Polyclonal Antibody, Unconjugated (OABF01707) 1:200, overnight at 4C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37C.

Formalin-fixed and paraffin-embedded mouse intestine labeled with Anti-PAI1/PLANH1/Serpine 1 Polyclonal Antibody, Unconjugated (OABF01707) 1:200, overnight at 4C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37C.DAPI was used to stain the cell nuclei

Product Info

• Predicted Species Reactivity: Bovine|Dog|Guinea Pig|Horse|Human|Mouse|Porcine|Rat|Sheep
• Product Format: Liquid. Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin
• Additional Information: Subcellular location: Secreted
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human PAI1/PLANH1
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: 1:100 - 500 Fluorescent-IHC: 1:50 - 200

Target Info

• Gene Symbol: SERPINE1
• Gene Full Name: serpin family E member 1
• Alias Symbols: endothelial plasminogen activator inhibitor;PAI;PAI1;PAI-1;PLANH1;plasminogen activator inhibitor 1;serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1;serpin E1;serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1.
• NCBI Gene Id: 5054
• Protein Name: Plasminogen activator inhibitor 1
• Description of Target: Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
• Uniprot ID: P05121