SERPINE1 Antibody - Biotin Conjugated (OACA01747)

Catalog No: OACA01747

Size:100ug

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Biotin
• Application: Enzyme-linked immunosorbent assay
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Plasminogen activator inhibitor 1 protein (24-398AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.'Pannekoek H., Veerman H., Lambers H., Diergaarde P., Verweij C.L., van Zonneveld A.-J., van Mourik J.A.EMBO J. 5:2539-2544(1986)
  [2] Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns.'Loskutoff D.J., Linders M., Keijer J., Veerman H., van Heerikhuizen H., Pannekoek H.Biochemistry 26:3763-3768(1987)
  [3] cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.'Ginsburg D., Zeheb R., Yang A.Y., Rafferty U.M., Andreasen P.A., Nielsen L., Dano K., Lebo R.V., Gelehrter T.D.J. Clin. Invest. 78:1673-1680(1986)
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: SERPINE1
• Gene Full Name: serpin family E member 1
• Alias Symbols: endothelial plasminogen activator inhibitor;PAI;PAI1;PAI-1;PLANH1;plasminogen activator inhibitor 1;serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1;serpin E1;serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1.
• NCBI Gene Id: 5054
• Protein Name: Plasminogen activator inhibitor 1
• Description of Target: Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
• Uniprot ID: P05121