SERPINA5 Protein (OPPA02068)

Catalog No: OPPA02068 (Formerly GWB-AF2EAD)

Size:2UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: The SERPINA5 solution contains 20mM Tris-HCl buffer pH-8., 1mM DTT, and 10% glycerol. Physical appearance: Sterile Filtered colorless solution.
• Host: E. Coli
  Product Introduction: SERPINA5 up regulateS TAFI activation by inhibiting the protein C activation. SERPINA5 is an significant regulator in the equilibrium between coagulation and fibrinolysis by differentially inhibiting the activation of TAFI and of Protein-C. SERPINA5 belongs to the serpin serine proteinase inhibitor family. SERPINA5 protein inhibits plasminogen activators as well as activated protein C. SERPINA5 is secreted in plasma and liver. SERPINA5 is involved in cell inflammation, proliferation, apoptosis, tumour cell migration, invasion, and metastasis. SERPINA5 controls the invasive potential of renal cell carcinoma by inhibiting urinary plasminogen activator secreted by the cells. SERPINA5 plays a role in regulating key serine proteases involved in metastatic prostate disease. The heparin binding site of SERPINA5 inhibitor is protease-dependent.
  Product Description: SERPINA5 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 408 amino acids (20-406 a.a.) and having a molecular mass of 45.9 kDa.The SERPINA5 is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: SERPINA5 although stable 4C for 4 weeks, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Peptide Sequence: MGSSHHHHHH SSGLVPRGSH MHRHHPREMK KRVEDLHVGA TVAPSSRRDF TFDLYRALAS AAPSQNIFFS PVSISMSLAM LSLGAGSSTK MQILEGLGLN LQKSSEKELH RGFQQLLQEL NQPRDGFQLS LGNALFTDLV VDLQDTFVSA MKTLYLADTF PTNFRDSAGA MKQINDYVAK QTKGKIVDLL KNLDSNAVVI MVNYIFFKAK WETSFNHKGT QEQDFYVTSE TVVRVPMMSR EDQYHYLLDR NLSCRVVGVP YQGNATALFI LPSEGKMQQV ENGLSEKTLR KWLKMFKKRQ LELYLPKFSI EGSYQLEKVL PSLGISNVFT SHADLSGISN HSNIQVSEMV HKAVVEVDES GTRAAAATGT IFTFRSARLN SQRLVFNRPF LMFIVDNNIL FLGKVNRP.

Target Info

• Gene Symbol: SERPINA5
• Alias Symbols: PCI, PAI3, PAI-3, PCI-B, PROCI, PLANH3
• NCBI Gene Id: 5104
• Protein Name: Plasma serine protease inhibitor
• Description of Target: Recombinant Human Serpin Peptidase Inhibitor, Clade A Member 5
• Uniprot ID: P05154
• Protein Accession #: NP_000615.3
• Protein Size (# AA): Recombinant