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- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for SEM1 Antibody (OACA03666) (OACA03666) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Unconjugated |
Application | Enzyme-linked immunosorbent assay|Immunohistochemistry |
Reconstitution and Storage | -20°C or -80°C |
Immunogen | Recombinant Human 26S proteasome complex subunit SEM1 protein (1-70AA) |
Purification | Protein G Purified |
Preservative | 0.03% Proclin 300 |
Formulation | 50% Glycerol, 0.01M PBS, PH 7.4 |
Purity | >95% |
Gene Symbol | SEM1 |
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Gene Full Name | SEM1 26S proteasome subunit |
Alias Symbols | 26S proteasome complex subunit DSS1;26S proteasome complex subunit SEM1;C7orf76;deleted in split hand/split foot protein 1;deleted in split-hand/split-foot 1;DSS1;ECD;PSMD15;SEM1 26S proteasome complex subunit;SHFD1;Shfdg1;SHFM1;SHSF1;split hand/foot deleted protein 1;split hand/foot malformation (ectrodactyly) type 1;split hand/foot malformation type 1 protein. |
NCBI Gene Id | 7979 |
Protein Name | 26S proteasome complex subunit SEM1 |
Description of Target | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. |
Uniprot ID | P60896 |
Protein Accession # | NP_006295 |
Nucleotide Accession # | NM_006304 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "SEM1 Antibody (OACA03666)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "SEM1 Antibody (OACA03666)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "SEM1 Antibody (OACA03666)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "SEM1 Antibody (OACA03666)"?
This target may also be called "26S proteasome complex subunit DSS1;26S proteasome complex subunit SEM1;C7orf76;deleted in split hand/split foot protein 1;deleted in split-hand/split-foot 1;DSS1;ECD;PSMD15;SEM1 26S proteasome complex subunit;SHFD1;Shfdg1;SHFM1;SHSF1;split hand/foot deleted protein 1;split hand/foot malformation (ectrodactyly) type 1;split hand/foot malformation type 1 protein." in publications.
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What is the shipping cost for "SEM1 Antibody (OACA03666)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "SEM1 Antibody (OACA03666)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "SEM1 Antibody (OACA03666)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "SEM1 Antibody (OACA03666)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "SEM1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "SEM1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "SEM1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "SEM1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "SEM1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "SEM1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.