Product Number |
P100963_P050 |
Product Page |
www.avivasysbio.com/eloc-antibody-n-terminal-region-p100963-p050.html |
Name |
ELOC Antibody - N-terminal region (P100963_P050) |
Protein Size (# AA) |
112 amino acids |
Molecular Weight |
12kDa |
NCBI Gene Id |
6921 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
elongin C |
Description |
|
Alias Symbols |
SIII, TCEB1 |
Peptide Sequence |
Synthetic peptide located within the following region: EHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRY |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Yu,X., et al., (2003) Science 302 (5647), 1056-1060 |
Description of Target |
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. |
Protein Interactions |
UBC; TCEB2; FUS; vif; METTL21C; SOCS4; CUL5; PRAME; POP1; MDM2; VHL; ASB18; ASB12; ASB14; ASB15; ASB9; ASB8; ASB7; ASB5; ASB10; ASB16; ASB13; ASB1; ASB3; APEX1; CUL2; Zswim8; ASB2; CPTP; CBX5; MRAS; JTB; RCAN2; SOCS1; CUL3; WNT7B; NEDD8; HIF1A; EFNB3; CYP |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-ELOC (P100963_P050) antibody |
Blocking Peptide |
For anti-ELOC (P100963_P050) antibody is Catalog # AAP31321 (Previous Catalog # AAPP02071) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human TCEB1 |
Uniprot ID |
Q15369 |
Protein Name |
elongin-C |
Sample Type Confirmation |
TCEB1 is strongly supported by BioGPS gene expression data to be expressed in Raji |
Protein Accession # |
NP_005639 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_005648 |
Tested Species Reactivity |
Human |
Gene Symbol |
ELOC |
Predicted Species Reactivity |
Human, Dog, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Dog: 100%; Human: 100%; Zebrafish: 100% |
Image 1 | Human Raji
| WB Suggested Anti-TCEB1 Antibody Titration: 0.2-1 ug/ml Positive Control: Raji cell lysateTCEB1 is strongly supported by BioGPS gene expression data to be expressed in Human Raji cells |
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